MI-3454 stin-d3 ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29

ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29

SAR502250 (0

Muscarine ((+)-Muscarine) chloride is a toxin that can stimulate the parasympathetic nervous system

an endogenous metabolite

Chemical Name: 5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1

MI-3454 stin-d3 ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29MI 3454 is an orally active, highly potent and selective menin MLL1 interaction inhibitor with an IC50 of 0. 51 nM. MI 3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1 rearranged or NPM1 mutated leukemia through downregulation of key genes involved in leukemogenesis. Product information CAS Number: 2134169 43 8 Molecular Weight: 636. 73 Formula: C32H35F3N8OS Chemical Name: N